ABSTRACT
Objective To investigate the curative effect and prognosis of double-plate fixation in adults with femoral shaft fractures.Methods Eighty patients with femoral shaft fractures treated in our hospital between March 2016 and February 2014 were randomly divided into an observation group and a control group,with 40 patients in each group.The observation group received treatment with double locking internal fixation,and the control group received dynamic compression plate treatment.Knee joint dysfunction,infection,and fractures were compared between the two groups.The hospital for special surgery (HSS) standard for evaluation of knee joint function and Karlstr(o)m-Olerud score for femoral fractures were used to assess the curative effect.Results In the observation group,the incidence rates of infection,knee joint dysfunction,and fracture were lower than that in the control group (P ＜ 0.05);the HSS score for knee joint function and clinical curative effect in the observation group were higher than those in the control group (P ＜ 0.05).Conclusion Double-plate fixation for adult femoral shaft fractures can effectively reduce complications and allows for early initiation of functional exercise.
ABSTRACT
BACKGROUND: Injectable hydrogel-chitosan is the latest developed material for cartilage tissue engineering. It provides a novel cell attachment mechanism. OBJECTIVE: To investigate the effect of allologous chondrocytes in combination with chitosan in repairing cartilage defects. DESIGN, TIME AND SETTING: Randomized controlled animal trial was performed at the Central Laboratory of China Medical University from November 2004 to March 2006. MATERIALS: Thirty 2-week-old New Zealand rabbits weighing 0.3 kg were selected to model cartilage defect. METHODS: Thirty rabbits were randomly divided into three groups. In the experimental group, the defects were repaired by the injection of second passage of chondrocytes (2.5?1011 L-1) combined with chitosan into articular capsule; the cell suspension group was only injected with chondrocyte suspension (2.5?1011 L-1); the control group was not given any treatment. MAIN OUTCOME MEASURES: The animals were sacrificed at the 4th, 8th, and 12th weeks after operation, respectively to harvest the lateral condyle of knee joint. Hematine-eosine staining, gross and histological examinations, and electron microscopic evaluations were performed to observe the repair condition. RESULTS: The gross observation showed that there was no obvious swelling or other inflammatory responses in each rabbits. Histological examination suggested that in the experimental group, the cartilage defects were repaired by the hyaline cartilage tissue with smooth surface, which integrated smoothly with articular cartilage at 12 weeks after operation. No obvious defect repair was observed in the other groups. The transmission electron microscopic observation showed that in the new-formation tissues of the experimental group, there were round or oval chondrocytes, and abundant rough endoplasmic reticulum, ribosome and Golgi complex in cytoplasm. At 8 to 12 weeks, plenty of collagen fibers were found in cell suspension group. In the control group, only fibrous tissues were seen on the surface of defects. CONCLUSION: The articular cartilage defects of rabbits are repaired with allograft of chondrocytes seeded onto chitosan, indicating chitosan can serve as carrier in cell transplantation.